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Catalog #
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DMG-1A1-200
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Size
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200 Reactions
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Store At
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-20°C
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Human cytochrome P450 1A1 (CYP1A1) is a member of the monooxygenase superfamily of enzymes that are involved
in the synthesis of cholesterol, steroids, and other lipids. It is a member of subfamily 1A which is aromatic
compound-inducible and is highly homologous to CYP1A2, especially between exons 2, 4, 5, and 6, even though
their regulatory elements vary1.
CYP1A1 is expressed in many tissues including heart, muscle, liver and lung.
Among the various substrates are polycyclic aromatic hydrocarbons (PAHs), which are carcinogens2.
Some chemicals
can influence the activity of this enzyme. For example, the solvent tetrahydrofurane will inhibit CYP1A1, while
ethanol will induce3. The CYP1A1 gene is genetically
polymorphic among individuals and ethnic groups. Genetic
changes can influence enzymatic activity, and phenotypic changes are characterized into poor, intermediate,
extensive, and ultrarapid metabolism4. Single nucleotide polymorphisms (SNPs) have been associated with an
increased risk of some cancers such as oral squamous cell carcinoma5,
lung cancer6 and gall bladder cancer7.
The lung expression of CYP1A1 can be a biomarker of acute inhalation exposure to diesel exhaust particles and
may be implicated in an accelerated production of reactive oxygen species and subsequent aggravation of lung
injury8. CYP1A1 is located on the complementary strand of chromosome 15q22 and spans approximately 6 kb with
7 exons.
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