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Catalog #
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DMG-1A2-200
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Size
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200 Reactions
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Store At
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-20°C
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Human cytochrome P450 1A2 (CYP1A2) is a member
of the monooxygenase superfamily of enzymes involved in drug me-tabolism
and the synthesis of cholesterol, steroids, and other lipids. It
is a member of subfamily 1A which is aromatic compound-inducible.
CYP1A2 accounts for almost 15% of the CYP 450s present in the liver1.
The gene is highly homologous to CYP1A1, especially between exons
2, 4, 5, and 6, even though their regulatory elements vary2. Among the
various substrates of CYP1A2 are caffeine, the antiarrhythmic drug
mexiletine, and the bronchodilator theophylline. Some chemicals can
influence the activity of this enzyme. For example, tobacco smoke will
induce CYP1A2, while interferon will inhibit3. The CYP1A2 gene is
genetically polymorphic among individuals and ethnic groups and the
resultant phenotypic changes are characterized as poor, intermediate,
extensive, and ultrarapid metabolism4. Single nucleotide polymorphisms
(SNPs) in this gene have been implicated in increased metabolism of
caffeine5 and a predisposition to the disease porphyria cutanea tarda6.
The patterns of SNPs in CYP1A2 are shown to be consistent with human
evolutionary theory of African origin7. The gene is located on the
complementary strand of chromosome 15q22 and spans approximately
7 kb with 7 exons.
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