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Catalog #
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DMG-2A6-200
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Size
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200 Reactions
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Store At
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-20°C
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Human cytochrome P450 2A6 (CYP2A6) is a member of
the of the monooxygenase superfamily of enzymes involved in drug
metabolism and the synthesis of cholesterol, steroids, and other lipids.
It is the major member of the CYP2A subfamily expressed in the liver. It
metabolizes many endogenous compounds and xenobiotics. Compounds
such as nicotine, coumarin and several related molecules are at
least partially metabolized by CYP2A61. This enzyme is known to activate some carcinogens2. Some chemicals can influence the activity of
this enzyme. For example, barbiturates are known to induce CYP2A6,
while tranylcypromine will inhibit1. The CYP2A6 gene is genetically
polymorphic among individuals and ethnic groups. Genetic changes
such as single nucleotide polymorphisms (SNPs) can influence enzymatic
activity, and phenotypic changes are characterized into poor,
intermediate, extensive, and ultrarapid metabolism3. A genetic variant
of CYP2A6, CYP2A7, is found in close proximity in the genome but
codes for an inactive enzyme4. CYP2A6 is located on the complemen-tary
strand of chromosome 19q13 and spans approximately 6 kb with 9
exons.
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