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Catalog #
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DMG-2E1-200
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Size
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200 Reactions
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Store At
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-20°C
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Human cytochrome P450 2E1 (CYP2E1) is a member
of the monooxygenase superfamily of enzymes involved in drug metabolism
and synthesis of cholesterol, steroids and other lipids. It
is a major member of the CYP2E subfamily and is expressed in the
thymus and the liver. This subfamily metabolizes both endogenous
substrates, such as ethanol, acetone, and acetal, as well as exogenous
substrates including benzene, carbon tetrachloride, ethylene glycol and
nitrosamines1. Among the various inducible substrates of CYP2E1
are compounds such as acetaminophen, ethanol and isoniazid. Some
chemicals inhibit CYP2E1, namely Disulfiram and Ritonavir. The
CYP2E1 gene is genetically polymorphic among individuals and ethnic
groups. Genetic changes can influence enzymatic activity and the
resultant phenotypic changes are characterized into poor, intermediate,
extensive, and ultrarapid metabolism2. Increased activity of
CYP2E1 is documented immediately after alcohol consumption in
normal individuals, and remains elevated in obese individuals3, 4.
Several single nucleotide polymorphisms (SNPs) have been implicated
in such varied processes as gluconeogenesis, hepatic cirrhosis,
diabetes, and cancer5. The gene is located on chromosome 10q24 and
spans approximately 11 kb with 9 exons.
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