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Catalog #
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DMG-3A4-200
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Size
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200 Reactions
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Store At
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-20°C
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Human cytochrome P450 3A4 (CYP3A4) is a member
of the monooxygenase superfamily of enzymes involved in drug
metabolism and the synthesis of cholesterol, steroids and other lipids1.
CYP3A4, which encodes the protein nifedipine oxidase, is a member
of the glucocorticoid-inducible cytochrome P450 3A subfamily and is
expressed in the liver and small intestines2. CYP3A4 is responsible
for the metabolism of approximately half of all therapeutic drugs.
Among its various substrates are drugs such as codeine, cyclosporin
A, diazepam and erythromycin3. Some chemicals can influence the
activity of this enzyme. For example, St. John’s wort will induce
CYP3A4, while grapefruit juice will inhibit2. The CYP3A4 gene is
genetically polymorphic among individuals and ethnic groups. Single
nucleotide polymorphisms (SNPs) have been implicated in prostate
cancer, especially among African Americans4, and the development of
treatment-related leukemia resulting from altering the metabolism of
anticancer drugs5. This gene is part of a cluster of cytochrome P450
genes on the complementary strand of chromosome 7q21 and spans
approximately 27 kb with 13 exons.
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