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Catalog #
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DMG-POR-200
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Size
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200 Reactions
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Store At
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-20°C
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Human P450 oxidoreductase (POR) is the electron donor
for the cytochrome P450 superfamily of monooxygenases. POR
levels limit P450-dependent hydroxylation reactions1. The enzyme is
widely expressed in eukaryotic tissues, and at a high level in the liver.
Thyroid hormone levels regulate expression of POR
2
. Adrenocortico-tropic
hormone (ACTH) regulates expression in the adrenal cortex3.
Drugs can influence the expression of POR as with the cytochrome
P450s. It has been shown that the anti-thyroid drug, methimazole, can
cause a decrease in hepatic expression of POR. This decreased level
can be restored to normal by treatment with thyroxine2. Phenobarbital
induces POR synthesis in the liver3. Cytochrome P450s and POR are
each regulated by different hormonal controls and transcriptions factors
1. Little variation has been detected thus far in POR gene expression
between individuals4. This gene is located on chromosome 7q11
and spans approximately 32 kb with 15 exons.
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