Dimethyl Sulfoxide: Readily absorbed through the skin. Avoid contact in solutions containing toxic substances.

Dithiothreitol: Poison by intraperitoneal and intramuscular routes.

DNA in the control sample: The donors for the DNA control sample were tested for infectious agents and found to be negative. No testing methods, however, can offer complete assurance of the absence of infectious agents. Products of human origin, therefore, should be handled in a manner consistent with the possibility that an infectious agent may be present.

Ethylene Diamaine Tetraacetic Acid: Poison by intraperitoneal route. Experimental teratogenic and reproductive effects.

Glycerol: Moderately toxic by ingestion. A skin and eye irritant. Human and animal studies indicate potentially adverse effects on the reproductive system.

Magnesium Chloride: Mild eye and skin irritant. May cause kidney damage by ingestion.

Tris-hydroxymethylaminomethane: Moderately toxic by ingestion and intravenous routes.

Tween 20: Moderately toxic by intraperitoneal and intravenous routes. Experimental animal studies indicate potentially adverse effects on the reproductive system and the development of fetuses.

SUSPECTED CANCER AGENT: This product’s ingredients are not found on the following lists: FEDERAL OSHA Z LIST, IARC, NTP, CAL/OSHA.

IRRITANCY OF PRODUCT: While not tested, this product is not expected to cause irritancy to the skin. Mild eye irritation may occur if this product is splashed in the eye.

SENSITIZATION TO THE PRODUCT: The components of this product are not known to cause sensitization.

REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of this product and its components on the human reproductive system. Chemicals in the components of this system have teratogenic, mutagenic, and adverse reproductive effects at high doses in clinical studies involving animals. However, these chemicals are present in less than 1 percent concentration in these solutions.

• Mutagenicity: This product is not known to cause human mutagenic effects.
• Teratogenicity: This product is not known to cause human teratogenic effects.
• Reproductive Toxicity: This product is not known to cause reproductive toxicity effects.

MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: No specific medical conditions are known to be aggravated by exposure to this product.

RECOMMENDATIONS TO PHYSICIANS: This product is not expected to cause clinical symptoms. If such symptoms occur, treat the symptoms, while alleviating the cause.

EFFECT OF MATERIAL ON PLANTS or ANIMALS: Based on the volume of these solutions, and the packaging of the systems, no unusual effects on plants or animals are expected if this product is released into the environment.

EFFECT OF CHMICAL ON AQUATIC LIFE: Based on the volume of these solutions, and packaging of the systems, this product is not known to cause adverse effects on aquatic life.

EPA WASTE NUMBER: Not applicable

THIS MATERIAL IS NOT HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF TRANSPORTATION

SARA Threshold Planning Quantity: Not applicable
TSCA INVENTORY STATUS: The chemicals in this product are listed on the TSCA Inventory
CERCLA REPORTABLE QUANTITY (RQ): Ethylenediaminetetra-acetic Acid = 5000 lbs.
STATE REGULATORY INFORMATION: Chemicals in this product are covered under specific State regulation, as denoted below

LABELING (Precautionary Statements): Caution! May cause eye irritation. Ingestion may cause gastrointestinal distress. Avoid getting the chemical in your eyes. Avoid ingestion of this product. In case of contact, rinse eye or affected skin thoroughly with water for at least 15 minutes. If irritation persists, seek medical assistance. Store as directed in the product insert. Clean-up spills promptly. Refer to MSDS for additional information.

TARGET ORGANS: Eyes, Gastrointestinal tract

WHMIS SYMBOL: Not applicable

CAS #- This is the Chemical Abstract Service Number which is uniquely identifies each constituent. It is used for computer-related searching.

EXPOSURE LIMITS IN AIR:

ACGIH- American Conference of Governmental Industrial Hygienists, a professional association which establishes exposure limits.

TLV- Threshold Limit Value: an airborne concentration of a substance which represents conditions under which it is generally believed that nearly all workers may be repeatedly exposed without adverse effect. The duration must be considered, including the 8-hour Time Weighted Average (TWA), the 15-minute Short Term Exposure Limit, and the instantaneous Ceiling Level. Skin adsorption effects must also be considered.

OSHA- U.S. Occupational Safety and Health Administration

PEL- Permissible Exposure Limit- this exposure value means exactly the same as TLV, except that it is enforceable by OSHA. The IDLH- Immediately Dangerous to Life and Health level represents a concentration from which one can escape within 30-minutes without suffering escape-preventing or permanent injury. The DFG-MAK is the Republic of Germany’s Maximum Exposure Level, similar to the U.S. PEL. NIOSH is the National Institute of Occupational Safety and Health, which is the research arm of the U.S. Occupational Safety and Health Administration (OSHA). NIOSH issues exposure guidelines called Recommended Exposure Levels (RELs). When no exposure guidelines established, an entry of NE is made for reference.

FLAMMABILITY LIMITS IN AIR: Much of the information related to fire and explosion is derived from the National Fire Protection Association (NFPA). LEL- is the lowest percent of vapor in air, by volume, that will explode or ignite in the presence of an ignition source. UEL- the highest percent of vapor in air, by volume, that will explode or ignite in the presence of an ignition source.

TOXICOLOGICAL INFORMATION
Possible health hazards as derived from human data, animal studies, or from the results of studies with similar compounds are presented. Definitions of some terms used in this section are: LD50- Lethal Dose (solids & liquids) which kills 50% of the exposed animals; LC50- Lethal Concentration (gases) which kills 50% of the exposed animals; ppm- concentration expressed in parts of material per million parts of air or water; mg/m3- concentration expressed in weight of substance per volume of air; mg/kg- quantity of material, by weight, administered to test a subject, based on their body weight in kg. Data from several sources are used to evaluate the cancer-causing potential of the material. The sources are: IARC- the International Agency for Research on Cancer; NTP- the National Toxicology Program; RTECS- the Registry of Toxic Effects of Chemical Substance; OSHA and CAL/OSHA. IARC and NTP rate chemicals on a scale of decreasing potential to cause human cancer with rankings from 1 to 4. Subrankings (2A, 2B, etc.) are also used. Other measures of toxicity include TDLo the lowest dose to cause a symptom; TDo, LDLo, and LDo, the lowest dose to cause death.

REGULATORY INFORMATION
This section explains the impact of various laws and regulations on the material. EPA is the U.S. Environmental Protection Agency. WHMIS is the Canadian Workplace Hazard Information System. DOT and CTC are the U.S. Department of Transportation and the Canadian Transportation Commission, respectively. These are: Superfund Amendments and Reauthorization Act (SARA); the Toxic Substance Control Act (TSCA); Marine Pollutant status according to the DOT; California’s Safe Drinking Water Act (Proposition 65); the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund); and various state regulations. This section also includes information on the precautionary warnings which appear on the materials.